Century-old tumours offer rare cancer clues
نویسندگان
چکیده
منابع مشابه
Conformational Variations of a Key Enzyme Offer Clues to Cancer-Drug Resistance
Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has been shown to cause G2 cell cycle arrest in human cells by inducing ATR-mediated inactivation of p34cdc2, but factors directly engaged in this process remain unknown. We used tandem affinity purification to isolate native Vpr complexes. We found that damaged DNA binding protein 1 (DDB1), viral protein R binding protein (VPRBP...
متن کاملNew clues to old yeast.
The yeast Saccharomyces cerevisiae has been used as an experimental model for the genetic and molecular dissecton of the aging process for the past decade. This period has seen the implication of some 30 genes in yeast aging. These genes encode a wide array of biochemical functions, suggesting the participation of multiple molecular mechanisms of aging. However, four principles appear to be at ...
متن کاملClues from a rare decay
According to the standard model of particle physics, matter consists of three “families” of quarks and leptons. Each family contains four types of particles: two quarks and two leptons. Ordinary matter consists essentially of particles of the first family: the up and down quarks, which are strongly bound inside protons and neutrons; the electrons; and the electron-neutrinos, which are abundantl...
متن کاملGene variants offer clues to high-risk childhood ALL.
R esearchers have identified a new genetic fingerprint in pediatric acute lymphoblastic leukemia (ALL) that may predict which children already at high risk for relapse will have the worst survival. The finding, which adds to the growing knowledge about the molecular makeup of these high-risk cancers, also casts light on the ethnic disparities in childhood leukemia. Survival in pediatric ALL, th...
متن کاملUnraveling 50-Year-Old Clues Linking Neurodegeneration and Cancer to Cycad Toxins: Are microRNAs Common Mediators?
Recognition of overlapping molecular signaling activated by a chemical trigger of cancer and neurodegeneration is new, but the path to this discovery has been long and potholed. Six conferences (1962-1972) examined the puzzling neurotoxic and carcinogenic properties of a then-novel toxin [cycasin: methylazoxymethanol (MAM)-β-d-glucoside] in cycad plants used traditionally for food and medicine ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2017
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature.2017.21975